REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics

RL Carhart-Harris, KJ Friston, EL Barker - Pharmacological reviews, 2019 - Elsevier
This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

[HTML][HTML] Canalization and plasticity in psychopathology

RL Carhart-Harris, S Chandaria, DE Erritzoe… - …, 2023 - Elsevier
This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

RL Carhart-Harris, M Bolstridge, CMJ Day, J Rucker… - …, 2018 - Springer
Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …

Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression

L Roseman, DJ Nutt, RL Carhart-Harris - Frontiers in pharmacology, 2018 - frontiersin.org
Introduction: It is a basic principle of the “psychedelic” treatment model that the quality of the
acute experience mediates long-term improvements in mental health. In the present paper …

Psychedelics and the essential importance of context

RL Carhart-Harris, L Roseman… - Journal of …, 2018 - journals.sagepub.com
Psychedelic drugs are making waves as modern trials support their therapeutic potential
and various media continue to pique public interest. In this opinion piece, we draw attention …

The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world

R Watts, H Kettner, D Geerts, S Gandy, L Kartner… - …, 2022 - Springer
Rationale A general feeling of disconnection has been associated with mental and
emotional suffering. Improvements to a sense of connectedness to self, others and the wider …

Patients' accounts of increased “connectedness” and “acceptance” after psilocybin for treatment-resistant depression

R Watts, C Day, J Krzanowski, D Nutt… - Journal of …, 2017 - journals.sagepub.com
Objective: To identify patients' perceptions of the value of psilocybin as a treatment for
depression. Method: Twenty patients enrolled in an open-label trial of psilocybin for …

The entropic brain-revisited

RL Carhart-Harris - Neuropharmacology, 2018 - Elsevier
The entropic brain hypothesis proposes that within upper and lower limits, after which
consciousness may be lost, the entropy of spontaneous brain activity indexes the …

Predicting responses to psychedelics: a prospective study

ECHM Haijen, M Kaelen, L Roseman… - Frontiers in …, 2018 - frontiersin.org
Responses to psychedelics are notoriously difficult to predict, yet significant work is currently
underway to assess their therapeutic potential and the level of interest in psychedelics …

Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory

L Roseman, E Haijen, K Idialu-Ikato… - Journal of …, 2019 - journals.sagepub.com
Background: Psychedelic therapy is gaining recognition and the nature of the psychedelic
experience itself has been found to mediate subsequent long-term psychological changes …