REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics
This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
[HTML][HTML] Canalization and plasticity in psychopathology
RL Carhart-Harris, S Chandaria, DE Erritzoe… - …, 2023 - Elsevier
This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …
model of a general factor of psychopathology. To achieve this, we have distinguished …
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …
Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression
Introduction: It is a basic principle of the “psychedelic” treatment model that the quality of the
acute experience mediates long-term improvements in mental health. In the present paper …
acute experience mediates long-term improvements in mental health. In the present paper …
Psychedelics and the essential importance of context
RL Carhart-Harris, L Roseman… - Journal of …, 2018 - journals.sagepub.com
Psychedelic drugs are making waves as modern trials support their therapeutic potential
and various media continue to pique public interest. In this opinion piece, we draw attention …
and various media continue to pique public interest. In this opinion piece, we draw attention …
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world
Rationale A general feeling of disconnection has been associated with mental and
emotional suffering. Improvements to a sense of connectedness to self, others and the wider …
emotional suffering. Improvements to a sense of connectedness to self, others and the wider …
Patients' accounts of increased “connectedness” and “acceptance” after psilocybin for treatment-resistant depression
Objective: To identify patients' perceptions of the value of psilocybin as a treatment for
depression. Method: Twenty patients enrolled in an open-label trial of psilocybin for …
depression. Method: Twenty patients enrolled in an open-label trial of psilocybin for …
The entropic brain-revisited
RL Carhart-Harris - Neuropharmacology, 2018 - Elsevier
The entropic brain hypothesis proposes that within upper and lower limits, after which
consciousness may be lost, the entropy of spontaneous brain activity indexes the …
consciousness may be lost, the entropy of spontaneous brain activity indexes the …
Predicting responses to psychedelics: a prospective study
Responses to psychedelics are notoriously difficult to predict, yet significant work is currently
underway to assess their therapeutic potential and the level of interest in psychedelics …
underway to assess their therapeutic potential and the level of interest in psychedelics …
Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory
Background: Psychedelic therapy is gaining recognition and the nature of the psychedelic
experience itself has been found to mediate subsequent long-term psychological changes …
experience itself has been found to mediate subsequent long-term psychological changes …