Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Many patients with immunoglobulin A nephropathy (IgAN) progress to kidney failure even
with optimal supportive care. An improved understanding of the pathophysiology of IgAN in …

CD4+ T cells play fundamental roles in orchestrating immune responses and tissue
homeostasis. However, our inability to associate peptide human leukocyte antigen class-II …

Complement system (CS) dysregulation is a key factor in the pathogenesis of different
autoimmune diseases playing a central role in many immune innate and adaptive …

Abstract Background Primary Sjögren's syndrome (pSS) is an autoimmune condition that
causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS …

Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders
and affects autoantibody diversity and disease subgroups. The primary objective of this …

Objective To report the differences in phenotypic characteristics, disease course, and
outcome in monogenic and sporadic childhood lupus (SC-lupus) from a single tertiary …

Autoimmune diseases constitute a broad, heterogenous group with many diverse and often
overlapping symptoms. Even so, they are traditionally classified as either systemic …

Approximately one-third of patients with myeloid disorders like myelodysplastic syndrome
(MDS) and chronic myelomonocytic leukemia (CMML) exhibit inflammatory and autoimmune …

Simple Summary Melanoma is an immunogenic tumor, so its outcomes and the efficacy of
immunotherapy must be linked to the immune component. In this study, we aimed to find …