Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy
leading to end stage renal disease in approximately 60% of patients. Over the last decade, a …

Background Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of
chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) …

The complement system labels microbes and host debris for clearance. Degradation of
surface-bound C3b is pivotal to direct immune responses and protect host cells. How the …

The complement system is a key component of innate and adaptive immune responses.
Complement regulation is critical for prevention and control of disease. We have determined …

Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess
amounts of cell-free heme intravascularly and consumption of the protective heme …

Factor I (FI) is one of the main inhibitors of complement activity, and numerous rare coding
variants have been reported in patients with age-related macular degeneration, atypical …

Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI
function increases complement activation, contributing to diseases such as age-related …

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …

Deficiency of complement factor I is a rare immunodeficiency that typically presents with
increased susceptibility to encapsulated bacterial infections. However, non-infectious …