Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

SA Sakowski, EJ Koubek, KS Chen… - Annals of …, 2024 - Wiley Online Library
Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

SM Jacob, S Lee, SH Kim, KA Sharkey… - Nature Reviews …, 2024 - nature.com
Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

[HTML][HTML] Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a …

DG Jang, J Dou, EJ Koubek, S Teener, L Zhao… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background: The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic
and environmental factors. This study investigates associations between metal measures in …

Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study

SA Goutman, J Boss, DG Jang, C Piecuch… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Background: Environmental exposures impact amyotrophic lateral sclerosis (ALS) risk and
progression, a fatal and progressive neurodegenerative disease. Better characterization of …

Cognitive reserve as a modulator of cognitive decline and of behavioral symptoms in patients with amyotrophic lateral sclerosis

S Simão, M Oliveira Santos, M Gromicho… - … Lateral Sclerosis and …, 2024 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) has heterogeneous manifestations ranging
from motor neuron degeneration to cognitive and behavioral impairment. This study aims to …

Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a …

DG Jang, JF Dou, EJ Koubek, S Teener… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic
and environmental factors. This study investigates associations between metal measures in …