The prevalence of child and adolescent obesity has plateaued at high levels in most high-
income countries and is increasing in many low-income and middle-income countries …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …

Abstract Objective Leptin receptor (LepR) deficiency is an autosomal-recessive endocrine
disorder causing early-onset severe obesity, hyperphagia and pituitary hormone …

Obesity is a multifactorial and complex disease that often manifests in early childhood with a
lifelong burden. Polygenic and monogenic obesity are driven by the interaction between …

Context Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt
signaling through the melanocortin-4 receptor (MC4R) pathway, resulting in hyperphagia …

Monogenic non-syndromic obesity is characterized by severe early-onset obesity with
abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms …

Obesity, defined by an excess of body fat impacting on health, is a complex disease
resulting from the interaction between many genetic/epigenetic factors and environmental …

Background Recent studies have shown that obesity is largely influenced by heredity and
created by the interactions between several genes and environmental and behavioral …

Background Underlying medical causes of obesity (endocrine disorders, genetic obesity
disorders, cerebral or medication-induced obesities) are thought to be rare. Even in …