The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited
by the time required to generate stable mutant lines. We describe a system for gene …

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in
zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes …

The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

How diverse cell fates and complex forms emerge and feed back to each other to sculpt
functional organs remains unclear. In the developing heart, the myocardium transitions from …

In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like
network of cardiomyocytes that is critical for contraction and conduction, ventricular …