Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment

YJ Zhang, JL Guo, J Xue, CL Bai, Y Guo - Environmental Pollution, 2021 - Elsevier
Phthalates are plasticizers in various products and regarded as endocrine disruptors due to
their anti-androgen effects. Environmental occurrence and toxicities of parent phthalates …

Obesity II: Establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Lycopene preventing DEHP-induced renal cell damage is targeted by aryl hydrocarbon receptor

MZ Li, Y Zhao, HR Wang, M Talukder… - Journal of agricultural …, 2021 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is an environmentally persistent and bioaccumulative
plasticizer. Accumulation of DEHP in the body can eventually cause kidney damage. As a …

Obesogenic endocrine disrupting chemicals: identifying knowledge gaps

A Veiga-Lopez, Y Pu, J Gingrich… - Trends in Endocrinology & …, 2018 - cell.com
Endocrine disrupting chemicals (EDCs) are compounds that are part of everyday consumer
products and industrial manufacturing processes. EDCs can interfere with the endocrine …

The role of persistent organic pollutants in obesity: a review of laboratory and epidemiological studies

J Aaseth, D Javorac, AB Djordjevic, Z Bulat, AV Skalny… - Toxics, 2022 - mdpi.com
Persistent organic pollutants (POPs) are considered as potential obesogens that may affect
adipose tissue development and functioning, thus promoting obesity. However, various …

[HTML][HTML] Adipogenesis regulation and endocrine disruptors: emerging insights in obesity

JE González-Casanova, SL Pertuz-Cruz… - BioMed Research …, 2020 - hindawi.com
Endocrine disruptors (EDs) are defined as environmental pollutants capable of interfering
with the functioning of the hormonal system. They are environmentally distributed as …

Midpregnancy Phthalate and Phenol Biomarkers in Relation to Infant Body Composition: The Healthy Start Prospective Cohort

DR Stevens, AP Starling, PA Bommarito… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Gestational phthalate and phenol exposure disrupts adipogenesis, contributing
to obesity in mice. Whether gestational phthalate or phenol exposure is associated with …

Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways

H Mohammadi, S Ashari - Environmental Science and Pollution Research, 2021 - Springer
The wide use of phthalates, as phthalates are used in the manufacturing of not only plastics
but also many others goods, has become a main concern in the current century because of …

Reciprocal effect of environmental stimuli to regulate the adipogenesis and osteogenesis fate decision in bone marrow-derived mesenchymal stem cells (BM-MSCs)

X Xu, L Zhao, PD Terry, J Chen - Cells, 2023 - mdpi.com
Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …

Di (2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications

X Zhang, W Qi, Q Xu, X Li, L Zhou, L Ye - Environmental Science and …, 2022 - Springer
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine
disruptor. DEHP can be absorbed into the human body through the air, food, water, and skin …