The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

Aims The anticoagulant rivaroxaban is an oral, direct F actor X a inhibitor for the
management of thromboembolic disorders. Metabolism and excretion involve cytochrome …

Context Drug-drug interactions are a preventable cause of morbidity and mortality, yet their
consequences in the community are not well characterized. Objective To determine whether …

Essentials• Rivaroxaban and dabigatran are substrates of the P‐glycoprotein (P‐gp)
encoded by the ABCB1 gene.• We tested the effect of ABCB1 polymorphisms and of a P‐gp …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …

Objective Extracts of St John's wort (Hypericum perforatum) are widely used in the treatment
of depression, often as an over‐the‐counter drug. In contrast to its frequent use, knowledge …

The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

Cellular and molecular aspects of drug transport in the kidney. The kidney plays an
important role in the elimination of numerous hydrophilic xenobiotics, including drugs …