Tetanus toxin fragment C: structure, drug discovery research and production

C Bayart, A Mularoni, N Hemmani, S Kerachni, J Jose… - Pharmaceuticals, 2022 - mdpi.com
Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in
vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In …

DNA vaccination strategies for anti-tumour effective gene therapy protocols

E Signori, S Iurescia, E Massi, D Fioretti… - Cancer immunology …, 2010 - Springer
After more than 15 years of experimentation, DNA vaccines have become a promising
perspective for tumour diseases, and animal models are widely used to study the biological …

Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

J Huang, S Alexey, J Li, T Jones, G Grande, L Douthit… - Leukemia, 2019 - nature.com
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The
current rapid development of chimeric antigen receptor T-cell (CAR-T-cell or CART) therapy …

Epitope-driven DNA vaccine design employing immunoinformatics against B-cell lymphoma: a biotech's challenge

S Iurescia, D Fioretti, VM Fazio, M Rinaldi - Biotechnology advances, 2012 - Elsevier
DNA vaccination has been widely explored to develop new, alternative and efficient
vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific …

Recent advances in design of immunogenic and effective naked DNA vaccines against cancer

D Fioretti, S Iurescia, M Rinaldi - Recent patents on anti-cancer …, 2014 - ingentaconnect.com
A variety of clinical trials for vaccines against cancer have provided evidence that DNA
vaccines are well tolerated and have an excellent safety profile. DNA vaccines require much …

Idiotypes as immunogens: facing the challenge of inducing strong therapeutic immune responses against the variable region of immunoglobulins

A López-Requena, OR Burrone… - Frontiers in …, 2012 - frontiersin.org
Idiotype (Id)-based immunotherapy has been exploited as cancer treatment option.
Conceived as therapy for malignancies bearing idiotypic antigens, it has been also …

Co-expression of tetanus toxin fragment C in Escherichia coli with thioredoxin and its evaluation as an effective subunit vaccine candidate

YZ Yu, ZW Gong, Y Ma, SM Zhang, HQ Zhu, WB Wang… - Vaccine, 2011 - Elsevier
The receptor-binding domain of tetanus toxin (THc), which mediates the binding of the toxin
to the nerve cells, is a candidate subunit vaccine against tetanus. In this study one synthetic …

Strategies for improving DNA vaccine performance

S Iurescia, D Fioretti, M Rinaldi - DNA Vaccines: Methods and Protocols, 2014 - Springer
The goal of active vaccination is to induce all the immune effector pathways and to establish
immunological memory allowing prolonged surveillance against pathogens or cancer cells …

In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases

D Fioretti, S Iurescia, V Michele Fazio… - Current drug …, 2013 - ingentaconnect.com
Electroporation is the process commonly referred to the transient increase in the
permeability of cell membranes on submission to electric field pulses. Electroporation has …

Cancer immunoinformatics: a new assistant tool for malignant disease research

W Wang, R Zhang, H Liang, H Zhang, F Li… - Chinese medical …, 2014 - journals.lww.com
Cancer immunoinformatics: a new assistant tool for malignant... : Chinese Medical Journal
Cancer immunoinformatics: a new assistant tool for malignant disease research : Chinese …