Tetanus toxin fragment C: structure, drug discovery research and production
Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in
vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In …
vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In …
DNA vaccination strategies for anti-tumour effective gene therapy protocols
E Signori, S Iurescia, E Massi, D Fioretti… - Cancer immunology …, 2010 - Springer
After more than 15 years of experimentation, DNA vaccines have become a promising
perspective for tumour diseases, and animal models are widely used to study the biological …
perspective for tumour diseases, and animal models are widely used to study the biological …
Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies
J Huang, S Alexey, J Li, T Jones, G Grande, L Douthit… - Leukemia, 2019 - nature.com
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The
current rapid development of chimeric antigen receptor T-cell (CAR-T-cell or CART) therapy …
current rapid development of chimeric antigen receptor T-cell (CAR-T-cell or CART) therapy …
Epitope-driven DNA vaccine design employing immunoinformatics against B-cell lymphoma: a biotech's challenge
DNA vaccination has been widely explored to develop new, alternative and efficient
vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific …
vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific …
Recent advances in design of immunogenic and effective naked DNA vaccines against cancer
D Fioretti, S Iurescia, M Rinaldi - Recent patents on anti-cancer …, 2014 - ingentaconnect.com
A variety of clinical trials for vaccines against cancer have provided evidence that DNA
vaccines are well tolerated and have an excellent safety profile. DNA vaccines require much …
vaccines are well tolerated and have an excellent safety profile. DNA vaccines require much …
Idiotypes as immunogens: facing the challenge of inducing strong therapeutic immune responses against the variable region of immunoglobulins
A López-Requena, OR Burrone… - Frontiers in …, 2012 - frontiersin.org
Idiotype (Id)-based immunotherapy has been exploited as cancer treatment option.
Conceived as therapy for malignancies bearing idiotypic antigens, it has been also …
Conceived as therapy for malignancies bearing idiotypic antigens, it has been also …
Co-expression of tetanus toxin fragment C in Escherichia coli with thioredoxin and its evaluation as an effective subunit vaccine candidate
YZ Yu, ZW Gong, Y Ma, SM Zhang, HQ Zhu, WB Wang… - Vaccine, 2011 - Elsevier
The receptor-binding domain of tetanus toxin (THc), which mediates the binding of the toxin
to the nerve cells, is a candidate subunit vaccine against tetanus. In this study one synthetic …
to the nerve cells, is a candidate subunit vaccine against tetanus. In this study one synthetic …
Strategies for improving DNA vaccine performance
S Iurescia, D Fioretti, M Rinaldi - DNA Vaccines: Methods and Protocols, 2014 - Springer
The goal of active vaccination is to induce all the immune effector pathways and to establish
immunological memory allowing prolonged surveillance against pathogens or cancer cells …
immunological memory allowing prolonged surveillance against pathogens or cancer cells …
In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases
Electroporation is the process commonly referred to the transient increase in the
permeability of cell membranes on submission to electric field pulses. Electroporation has …
permeability of cell membranes on submission to electric field pulses. Electroporation has …
Cancer immunoinformatics: a new assistant tool for malignant disease research
Cancer immunoinformatics: a new assistant tool for malignant... : Chinese Medical Journal
Cancer immunoinformatics: a new assistant tool for malignant disease research : Chinese …
Cancer immunoinformatics: a new assistant tool for malignant disease research : Chinese …