Germ granules are the hallmark of all germ cells. These membrane-less, electron-dense
structures were first observed over 100 years ago. Today, their role in regulating and …

The small β-barrel (SBB) is an ancient protein structural domain characterized by extremes:
it features a broad range of structural varieties, a deeply intricate evolutionary history, and it …

piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

Tudor domain-containing (TDRD) proteins, as a family of evolutionarily conserved proteins,
have been studied extensively in recent years in terms of their biological and biochemical …

The assembly of large RNA-protein granules occurs in germ cells of many animals and
these germ granules have provided a paradigm to study structure-functional aspects of …

Biomolecular condensates (BMCs) can facilitate or inhibit diverse cellular functions. BMC
formation is driven by noncovalent protein–protein, protein–RNA, and RNA–RNA …

The P-element–induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway plays a
central role in transposon silencing and genome protection in the animal germline. A family …

Aub guided by piRNAs ensures genome integrity by cleaving retrotransposons, and genome
propagation by trapping mRNAs to form the germplasm that instructs germ cell formation …

Throughout metazoa, germ cells assemble RNA-protein organelles (germ granules). In
Drosophila ovaries, perinuclear nuage forms in the nurse cells, while compositionally similar …

Membraneless organelles are RNA–protein assemblies which have been implicated in post‐
transcriptional control. Germ cells form membraneless organelles referred to as germ …