Comprehensive overview of how to fade into succinate dehydrogenase dysregulation in cancer cells by naringenin-loaded chitosan nanoparticles

EM Ragab, AA Khamis, DME Gamal, TM Mohamed - Genes & Nutrition, 2024 - Springer
Mitochondrial respiration complexes play a crucial function. As a result, dysfunction or
change is intimately associated with many different diseases, among them cancer. The …

ROCK2 increases drug resistance in acute myeloid leukemia via metabolic reprogramming and MAPK/PI3K/AKT signaling

M Yan, X Luo, H Han, J Qiu, Q Ye, L Zhang… - International …, 2024 - Elsevier
Rho-associated coiled-coil kinase 2 (ROCK2) is classified as a member of the
serine/threonine protein kinase family and has been identified as a key driver of the …

The Warburg Effect Reinterpreted 100 yr on: A First-Principles Stoichiometric Analysis and Interpretation from the Perspective of ATP Metabolism in Cancer Cells

S Nath, R Balling - Function, 2024 - academic.oup.com
Abstract The Warburg Effect is a longstanding enigma in cancer biology. Despite the
passage of 100 yr since its discovery, and the accumulation of a vast body of research on …

Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

FJ Al Khazal, SM Bhat, Y Zhu… - Cancer & …, 2024 - Springer
Heterozygosity for loss-of‐function alleles of the genes encoding the four subunits of
succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly …

uL3 Regulates Redox Metabolism and Ferroptosis Sensitivity of p53-Deleted Colorectal Cancer Cells

C Brignola, A Pecoraro, C Danisi, N Iaccarino… - Antioxidants, 2024 - mdpi.com
Despite advancements in therapeutic strategies, the development of drug resistance and
metastasis remains a serious concern for the efficacy of chemotherapy against colorectal …

Bacteriophage-encoded 24B_1 molecule resembles herpesviral microRNAs and plays a crucial role in the development of both the virus and its host

S Bloch, N Lewandowska, J Zwolenkiewicz, P Mach… - Plos one, 2023 - journals.plos.org
The 24B_1 small non-coding RNA molecule has been identified in Escherichia coli after
induction of Shiga toxin-converting bacteriophage Φ24B. In this work, we focused on its …

Expression of Mitochondrial Long Non-Coding RNAs, MDL1 and MDL1AS, Are Good Prognostic and/or Diagnostic Biomarkers for Several Cancers, Including …

P Garrido, A Casas-Benito, IM Larrayoz… - Cancers, 2024 - mdpi.com
Simple Summary Personalized cancer medicine is based on the right classification of
patients that can, then, be treated according to their specific characteristics. This is …

[HTML][HTML] From electrons to cancer: Redox shift as a driving force of tumorigenesis

R Attal, A Bakkar, F Bouillaud, A Devin, M Henry… - Advances in Redox …, 2024 - Elsevier
Cancer cells are very diverse but mostly share a common metabolic property: they are
strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of …

Metabolism and Carcinogenesis: The Warburg Effect and Beyond

R Thomas - Journal of Carcinogenesis, 2024 - submissions.carcinogenesis.com
Abstract The Warburg Effect and Beyond," the research takes us on a tour of the complex
world of cellular metabolism and its significant effects on cancer. The Warburg Effect a …

Study of the Role of NRF2 in the Progression and Metabolic Adaptation of Glioblastoma

M Moubarak - 2024 - theses.hal.science
Glioblastoma (GB), the most aggressive form of brain tumor, poses substantial therapeutic
challenges due to its invasive behavior, treatment resistance, and genetic heterogeneity …