Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …

Iron deficiency, with or without iron-deficiency anemia, is so ubiquitous that it affects all
populations of the world irrespective of race, culture, or ethnic background. Despite all the …

Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin,
and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; …

Highlights•Artemisinin is a pro-drug that is activated by heme or iron.•Hemoglobin
degradation generates an artemisinin activator.•Parasite killing requires exposure to an …

Quinine extracted from the bark of the South American Cinchona spp tree was the first of all
antimalarials in western medicine and had been used since the 17th century. For more than …

Different types of thiosemicarbazone derivatives were designed and tested for their Drug-
Like Molecular (DLM) nature by using Lipinski and Veber rules. Subsequently, compounds …

Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua),
its characterization as a peroxide and preparation of the derivatives dihydroartemisinin …

The current model for hemoglobin ingestion and transport by intraerythrocytic Plasmodium
falciparum malaria parasites shares similarities with endocytosis. However, the model is …

Background Artesunate the most potent antimalarial is widely used for the treatment of
multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly …