Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and
other tauopathies. High-throughput screening in neurons derived from human induced …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively
expressed, cognate protein of the HSP70 family, which is central in many cellular processes …

The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

Among diseases whose cure is still far from being discovered, Alzheimer's disease (AD) has
been recognized as a crucial medical and social problem. A major issue in AD research is …

It is now known that proteins associated with neurodegenerative disease can spread
throughout the brain in a prionlike manner. However, the mechanisms regulating the trans …

Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …