Autophagy contributes to the maintenance of intracellular homeostasis in most cells of
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Mitochondria ensure the supply of cellular energy through the production of ATP via
oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Spermidine, a natural autophagy inducer, has a variety of health effects, such as antitumor,
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …

High incidences of morbidity and mortality associated with age-related diseases among the
elderly population are a socio-economic challenge. Aging is an irreversible and inevitable …

Recent advances in health care have improved the management of cardiometabolic
disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress …

Macroautophagy/autophagy is a conserved catabolic recycling pathway in which
cytoplasmic components are sequestered, degraded, and recycled to survive various stress …

Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …