Niemann-Pick type C (NPC) disease is a lysosomal storage disease in which endocytosed
cholesterol becomes sequestered in late endosomes/lysosomes (LEs/Ls) because of …

Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Alzheimer's disease (AD) is believed to be triggered by increased levels/aggregation of β-
amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD …

Since the discovery about 30 years ago (2-hydroxypropyl) beta-cyclodextrin, a highly
soluble derivative of beta-cyclodextrin, has become an approved excipient of drug …

Macroautophagy/autophagy failure with the accumulation of autophagosomes is an early
neuropathological feature of Alzheimer disease (AD) that directly affects amyloid beta (Aβ) …

There is extensive evidence that cholesterol and membrane lipids play a key role in
Alzheimer disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide …

Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein
enriched with β-sheet-rich intermediates has been suggested to play a role in the …

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is
markedly impaired in neurons in Alzheimer's disease and Alzheimer mouse models. We …

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder believed to
be initiated by accumulation of amyloid β (Aβ)-related peptides derived from proteolytic …

CLN3 Batten disease is an autosomal recessive, neurodegenerative, lysosomal storage
disease caused by mutations in CLN3, which encodes a lysosomal membrane protein …