G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins
(Figure 1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …

Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Abstract Urotensin II (U-II) is the most potent vasoconstrictor known, even more potent than
endothelin-1. It was first isolated from the fish spinal cord and has been recognized as a …

The identification of a human homolog of urotensin-II (U-II) and a novel, specific G-protein-
coupled receptor by Ames et al. in 1999 changed the perception that the U-II isopeptide …

The development of synthetic macrocycles represents a powerful approach toward the
identification of new protein binders or inhibitors of Protein-Protein Interactions (PPI) which …

In this study we describe the ability of two human urotensin‐II (hU‐II) derivatives [Pen5,
Orn8] hU‐II (4–11) and [Pen5, DTrp7, Orn8] hU‐II (4–11)(urantide) to block hU‐II‐induced …

Several peptides play an important role in physiological and pathological conditions into the
cardiovascular system. In addition to well-known vasoactive agents such as angiotensin II …

Urotensin II (UII) has been described as the most potent vasoconstrictor peptide and
recognized as the endogenous ligand of the orphan G protein-coupled receptor GPR14 …

Urotensin II receptor (UT) modulators that differentiate the effects of the endogenous cyclic
peptide ligands urotensin II (UII) and urotensin II-related peptide (URP) offer potential for …