In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …

The identification of intestinal stem cells as well as their malignant counterparts, colon
cancer stem cells, has undergone rapid development in recent years. Under physiological …

Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the
survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of …

There is an increasing demand for network analysis of protein-protein interactions (PPIs).
We introduce a web-based protein interaction network analysis platform (PINA), which …

Metabolism is a fundamental cellular function that can be reprogrammed by signaling
pathways and oncogenes to meet cellular requirements. An emerging paradigm is that …

Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz–
Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in …

Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers
patients has continued at a feverish pace following exciting developments linking energy …

Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function
mutations in the LKB1/STK11 serine/threonine kinase. PJS patients develop gastrointestinal …