Artemisinins as anticancer drugs: Novel therapeutic approaches, molecular mechanisms, and clinical trials
C Xu, H Zhang, L Mu, X Yang - Frontiers in Pharmacology, 2020 - frontiersin.org
Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in
vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging …
vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging …
Dihydroartemisinin: a potential drug for the treatment of malignancies and inflammatory diseases
R Yu, G Jin, M Fujimoto - Frontiers in oncology, 2021 - frontiersin.org
Dihydroartemisinin (DHA) has been globally recognized for its efficacy and safety in the
clinical treatment of malaria for decades. Recently, it has been found that DHA inhibits …
clinical treatment of malaria for decades. Recently, it has been found that DHA inhibits …
Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications
J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …
survival. This underscores the paramount necessity to explore and investigate novel …
Artemisinin-type drugs in tumor cell death: mechanisms, combination treatment with biologics and nanoparticle delivery
X Zhou, F Suo, K Haslinger, WJ Quax - Pharmaceutics, 2022 - mdpi.com
Artemisinin, the most famous anti-malaria drug initially extracted from Artemisia annua L.,
also exhibits anti-tumor properties in vivo and in vitro. To improve its solubility and …
also exhibits anti-tumor properties in vivo and in vitro. To improve its solubility and …
MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway
Y Wang, Y Zheng, Q Chen, Y Dai, T Li - Archives of biochemistry and …, 2021 - Elsevier
Micro–ribonucleic acids (miRNAs) are a class of conserved small non-coding RNAs
(sncRNAs) that post-transcriptionally regulate their downstream target genes. Existing …
(sncRNAs) that post-transcriptionally regulate their downstream target genes. Existing …
Anti-tumor mechanism of artesunate
X Fan, Y Yan, Y Li, Y Song, B Li - Frontiers in Pharmacology, 2024 - frontiersin.org
Artesunate (ART) is a classic antimalarial drug with high efficiency, low toxicity and
tolerance. It has been shown to be safe and has good anti-tumor effect. Existing clinical …
tolerance. It has been shown to be safe and has good anti-tumor effect. Existing clinical …
PD-1/PD-L1 interaction upregulates YAP1 expression in hepG2 cells through MAPK/ERK pathway
S Li, M Dai, F Wang, L Hao, C Feng… - Natural Product …, 2023 - journals.sagepub.com
Background Antibodies, which target programmed cell death protein-1 (PD-1) or its ligand
programmed death ligand-1 (PD-L1), can rescue T cells from an exhausted state and …
programmed death ligand-1 (PD-L1), can rescue T cells from an exhausted state and …
Interferon-Gamma-Inducible Protein 16 Inhibits Hepatocellular Carcinoma via Interferon Regulatory Factor 3 on Chemosensitivity
W Lin, Z Zhao, W Du, Z Ni, C Pan, P Fang, J Li… - Digestive Diseases and …, 2024 - Springer
Abstract Background and Aim Previous reports have suggested IFI16 as a tumor suppressor
in hepatocellular carcinoma (HC). Nonetheless, the biological significance of IFI16 and its …
in hepatocellular carcinoma (HC). Nonetheless, the biological significance of IFI16 and its …
Dihydroartemisinin inhibits TGF-β-induced fibrosis in human tenon fibroblasts via inducing autophagy
X Wang, W Song, F Zhang, R Huang - Drug Design, Development …, 2021 - Taylor & Francis
Background The formation of hypertrophic scars (HS) can result in the failure of glaucoma
surgery, and fibrosis is known to be closely associated with the progression of HS …
surgery, and fibrosis is known to be closely associated with the progression of HS …
Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers
Q Xia, J Zhang - Cell Biochemistry and Function, 2025 - Wiley Online Library
Autophagy is a physiologically regulated cellular process orchestrated by autophagy‐
related genes (ATGs) that, depending on the tumor type and stage, can either promote or …
related genes (ATGs) that, depending on the tumor type and stage, can either promote or …