Products of lipid peroxidation include a number of reactive lipid aldehydes such as
malondialdehyde, 4-hydroxy-nonenal, 4-oxo-nonenal, and isolevuglandins (IsoLGs) …

Oxidative injury due to elevated levels of reactive oxygen species is implicated in
cardiovascular diseases, Alzheimer's disease, lung and liver diseases, and many cancers …

The escalating global prevalence of type-2 diabetes (T2D) and obesity necessitates the
development of novel oral medications. Agonism at G-protein coupled receptor-119 …

Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric
pathogen that is the primary risk factor for carcinogenesis, associated with its induction of …

Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and
evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives …

Inflammation is associated with the formation of reactive oxygen species (ROS) and the
formation of lipid-derived compounds, such as isolevuglandins (IsoLGs), malondialdehyde …

Introduction Medicinal plants have over time played important roles in many indigenous
primary health care systems. Alchornea cordifolia, a widely distributed plant, is a commonly …

Colorectal cancer (CRC) is a major health problem worldwide. Dicarbonyl electrophiles,
such as isolevuglandins (isoLGs), are generated from lipid peroxidation and form covalent …

Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile
scavenger being developed as a nutritional supplement to help protect against the …

Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid.
Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to …