Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

The historical debate on the relative influences of genes (ie nature) and environment (ie
nurture) on human behaviour has been characterised by extreme positions leading to …

It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria
in skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

A number of studies have reported that a high-fat diet induces increases in mitochondrial
fatty acid oxidation enzymes in muscle. In contrast, in two recent studies raising plasma free …

Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant
offspring of patients with diabetes have≈ 30% less mitochondria in their skeletal muscles …

Dietary fructose has been suspected to contribute to development of metabolic syndrome.
However, underlying mechanisms of fructose effects are not well characterized. We …

Based on evidence that patients with type 2 diabetes (T2DM), obese insulin-resistant
individuals, and lean insulin-resistant offspring of parents with T2DM have∼ 30% less …

Diets high in fructose cause hypertriglyceridemia and insulin resistance in part due to
simultaneous induction of gluconeogenic and lipogenic genes in liver. We investigated the …