Autophagy genes in biology and disease
H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
Machinery, regulation and pathophysiological implications of autophagosome maturation
YG Zhao, P Codogno, H Zhang - Nature Reviews Molecular Cell …, 2021 - nature.com
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …
cytosolic materials are sequestered in a double-membrane autophagosome and …
[HTML][HTML] Biological functions of autophagy genes: a disease perspective
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …
cell types. The next challenge is to systematically understand cell-type-specific gene …
Autophagy and autophagy-related diseases: a review
T Ichimiya, T Yamakawa, T Hirano… - International journal of …, 2020 - mdpi.com
Autophagy refers to the process involving the decomposition of intracellular components via
lysosomes. Autophagy plays an important role in maintaining and regulating cell …
lysosomes. Autophagy plays an important role in maintaining and regulating cell …
Autophagy as a promoter of longevity: insights from model organisms
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
Autophagy and disease: unanswered questions
Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …
delivered to the lysosome for degradation and recycling. Autophagy has various …
A brief history of autophagy from cell biology to physiology and disease
N Mizushima - Nature cell biology, 2018 - nature.com
The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …
Macroautophagy in CNS health and disease
CJ Griffey, A Yamamoto - Nature Reviews Neuroscience, 2022 - nature.com
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …