Autophagy genes in biology and disease

H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Autophagy in healthy aging and disease

Y Aman, T Schmauck-Medina, M Hansen, RI Morimoto… - Nature aging, 2021 - nature.com
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Machinery, regulation and pathophysiological implications of autophagosome maturation

YG Zhao, P Codogno, H Zhang - Nature Reviews Molecular Cell …, 2021 - nature.com
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

[HTML][HTML] Biological functions of autophagy genes: a disease perspective

B Levine, G Kroemer - Cell, 2019 - cell.com
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

R Tian, A Abarientos, J Hong, SH Hashemi, R Yan… - Nature …, 2021 - nature.com
Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Autophagy and autophagy-related diseases: a review

T Ichimiya, T Yamakawa, T Hirano… - International journal of …, 2020 - mdpi.com
Autophagy refers to the process involving the decomposition of intracellular components via
lysosomes. Autophagy plays an important role in maintaining and regulating cell …

Autophagy as a promoter of longevity: insights from model organisms

M Hansen, DC Rubinsztein, DW Walker - Nature reviews Molecular cell …, 2018 - nature.com
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Autophagy and disease: unanswered questions

Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …

A brief history of autophagy from cell biology to physiology and disease

N Mizushima - Nature cell biology, 2018 - nature.com
The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …

Macroautophagy in CNS health and disease

CJ Griffey, A Yamamoto - Nature Reviews Neuroscience, 2022 - nature.com
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …