It has been suggested that long-term modifications of synaptic transmission constitute the
foundation of the processes by which information is stored in the central nervous system. A …

The integrity and preservation of the neuromuscular junction (NMJ), the interface between
the motor neuron and skeletal muscle, is critical for maintaining a healthy skeletal muscle …

Endocytosis of Trk (tropomyosin-related kinase) receptors is critical for neurotrophin signal
transduction and biological functions. However, the mechanism governing endocytosis of …

Postsynaptic cells generate positive and negative signals that retrogradely modulate
presynaptic function. At developing neuromuscular synapses, prolonged stimulation of …

To explore therapeutic potential of engineered neural tissue, we combined genetically
modified neural stem cells (NSCs) and poly (lactic acid-co-glycolic acid)(PLGA) polymers to …

During development, the brain goes through fundamental processes, including organization
of neural networks and plasticity. Environmental interventions may change initial brain …

Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional
deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount …

Background Maternal alcohol consumption is known to adversely affect fetal
neurodevelopment. While it is known that alcohol dose and timing play a role in the …

Abstract Neurotrophin-3 (NT-3) belongs to a family of growth factors called neurotrophins
whose actions are centered in the nervous system. NT-3 is structurally related to other …

Neurotrophins provide trophic and tropic support for different neuronal subpopulations in the
developing and adult nervous systems. Expression of the neurotrophins and their receptors …