Neurobiological mechanisms underlying psychostimulant use
RR Campbell, MK Lobo - Current Opinion in Neurobiology, 2023 - Elsevier
Rates of individuals struggling with psychostimulant use disorder (PSUD), defined as
chronic use of psychostimulants despite negative consequences, are growing rapidly over …
chronic use of psychostimulants despite negative consequences, are growing rapidly over …
[HTML][HTML] Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry
The dorsal striatum integrates prior and current information to guide appropriate decision-
making. Chronic stress and stimulant exposure interferes with decision-making, and can …
making. Chronic stress and stimulant exposure interferes with decision-making, and can …
Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice
CJ Browne, R Futamura, A Minier-Toribio, EM Hicks… - Science …, 2023 - science.org
Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …
More effective therapeutics will require a deeper understanding of molecular changes …
[HTML][HTML] Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
Drugs of abuse increase extracellular concentrations of dopamine in the nucleus
accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and …
accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and …
[HTML][HTML] A multivariate regressor of patterned dopamine release predicts relapse to cocaine
Understanding mesolimbic dopamine adaptations underlying vulnerability to drug relapse is
essential to inform prognostic tools for effective treatment strategies. However, technical …
essential to inform prognostic tools for effective treatment strategies. However, technical …
Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens
Cocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from
enduring cellular and molecular adaptations. Among substance use disorders, CUD is …
enduring cellular and molecular adaptations. Among substance use disorders, CUD is …
Abstinence-dependent effects of long-access cocaine self-administration on nucleus accumbens astrocytes are observed in male, but not female, rats
Accumulating evidence indicates significant consequences for astrocytes associated with
drug abuse. For example, reductions in structural features and synaptic colocalization of …
drug abuse. For example, reductions in structural features and synaptic colocalization of …
The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic …
A large body of work has demonstrated that cocaine-induced changes in transcriptional
regulation play a central role in the onset and maintenance of cocaine use disorder. An …
regulation play a central role in the onset and maintenance of cocaine use disorder. An …
Early life adversity: Epigenetic regulation underlying drug addiction susceptibility
JJ Winter, KL Rodríguez-Acevedo, M Dittrich… - Molecular and Cellular …, 2023 - Elsevier
Drug addiction is a leading cause of disability worldwide, with more than 70,000 Americans
dying from drug overdose in 2019 alone. While only a small percentage of chronic drug …
dying from drug overdose in 2019 alone. While only a small percentage of chronic drug …
Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice
DK Fischer, KS Krick, C Han, MT Woolf, EA Heller - Scientific Reports, 2022 - nature.com
Cocaine epigenetically regulates gene expression via changes in histone post-translational
modifications (HPTMs). We previously found that the immediate early gene Nr4a1 is …
modifications (HPTMs). We previously found that the immediate early gene Nr4a1 is …