Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include
prostaglandin (PG) D2, PGE2, PGF2α, PGI2, and thromboxne A2. They are synthesized and …

Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …

Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …

The relevance of cyclooxygenases (COX)-1 and-2 and their products to inflammation,
thrombosis and gastroprotection are well known. Their importance in the immune response …

Particulates such as silica crystal (silica) and aluminum salts (alum) activate the
inflammasome and induce the secretion of proinflammatory cytokines in macrophages …

The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …

Prostaglandin E2 (PGE2), a major COX metabolite, plays important roles in several facets of
tumor biology. We characterized the contribution of the PGE2 EP2 receptor to cancer …

Prostaglandins are lipid compounds that mediate many physiological effects. Prostaglandin
E2 (PGE 2) is the most abundant prostanoid in the human body, and synthesis of PGE 2 is …

Selenium (Se) is an essential trace element that functions in the form of the 21st amino acid,
selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with …