Identifying disease-specific genes based on their topological significance in protein networks

Z Dezső, Y Nikolsky, T Nikolskaya, J Miller… - BMC systems …, 2009 - Springer
Background The identification of key target nodes within complex molecular networks
remains a common objective in scientific research. The results of pathway analyses are …

S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes

M Sakaguchi, M Miyazaki, M Takaishi… - The Journal of cell …, 2003 - rupress.org
An increase in extracellular Ca2+ induces growth arrest and differentiation of human
keratinocytes in culture. We examined possible involvement of S100C/A11 in this growth …

Direct evidence that PKCα positively regulates wound re‐epithelialization: correlation with changes in desmosomal adhesiveness

HA Thomason, NH Cooper, DM Ansell… - The Journal of …, 2012 - Wiley Online Library
Non‐healing wounds cause considerable patient morbidity and represent a significant
economic burden. Central to wound repair is re‐epithelialization, a crucial process involving …

Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis

FV Abeele, Y Shuba, M Roudbaraki, L Lemonnier… - Cell calcium, 2003 - Elsevier
Ca2+ homeostasis mechanisms, in which the Ca2+ entry pathways play a key role, are
critically involved in both normal function and cancerous transformation of prostate epithelial …

Mitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells

Z Rusznák, G Bakondi, L Kosztka, K Pocsai, B Dienes… - Virchows Archiv, 2008 - Springer
The presence of TASK-3 channels has been described in a number of healthy and
malignantly transformed cells, showing mainly intracellular distribution with relatively …

Functional genomics of calcium channels in human melanoma cells

T Deli, N Varga, A Ádám, I Kenessey… - … journal of cancer, 2007 - Wiley Online Library
Ca2+‐signaling of human melanoma is in the focus of intensive research since the
identification of the role of WNT‐signaling in melanomagenesis. Genomic and functional …

EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs

JS Heo, YJ Lee, HJ Han - American Journal of Physiology …, 2006 - journals.physiology.org
We examined the effect of EGF on the proliferation of mouse embryonic stem (ES) cells and
their related signal pathways. EGF increased [3H] thymidine and 5-bromo-2′-deoxyuridine …

[HTML][HTML] TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes

B Beck, A Zholos, V Sydorenko, M Roudbaraki… - Journal of investigative …, 2006 - Elsevier
Muscarinic and purinergic receptors expressed in keratinocytes are an important part of a
functional system for cell growth. While several aspects of this process are clearly …

Generation and application of a reporter cell line for the quantitative screen of extracellular vesicle release

J Shpigelman, FS Lao, S Yao, C Li, T Saito… - Frontiers in …, 2021 - frontiersin.org
Extracellular vesicles (EVs) are identified as mediators of intercellular communication and
cellular regulation. In the immune system, EVs play a role in antigen presentation as a part …

Ca2+- and Volume-sensitive Chloride Currents Are Differentially Regulated by Agonists and Store-operated Ca2+ Entry

A Zholos, B Beck, V Sydorenko, L Lemonnier… - The Journal of general …, 2005 - rupress.org
Using patch-clamp and calcium imaging techniques, we characterized the effects of ATP
and histamine on human keratinocytes. In the HaCaT cell line, both receptor agonists …