The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with
systemic pathologies, including reproductive disorders in male diabetic patients. However …

The incidence of cerebral ischemia has increased in the past decades, and the high fatality
and disability rates seriously affect human health. Apelin is a bioactive peptide and the …

Highlights•Clinical characteristics of premature retinopathy.•Apelin/APJ signaling governing
angiogenesis for normal retinal vasculature.•Apelin/APJ signaling responses during the …

Apelin-APJ receptor signaling regulates vascular tone in cerebral and peripheral arteries.
We recently reported that apelin inhibits BKCa channel function in cerebral arteries …

CYP epoxygenase-derived epoxyeicosatrienoic acids (EETs) contribute to endothelium-
dependent hyperpolarization (EDH)-related dilation in multiple vascular beds. The present …

Endothelial cells form the innermost layer of all blood vessels and are the only vascular
component that remains throughout all vascular segments. The cerebral vasculature has …

Apelin Does Not Impair Coronary Artery Relaxation Mediated by Nitric Oxide-Induced
Channels Activation of BKCa Page 107 BRIEF RESEARCH REPORT published: 28 May 2021 …

Apelin is an endogenous ligand for APJ receptors, which are highly expressed throughout
the cardiovascular system, including coronary arteries. Apelin causes endothelium‐derived …