Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized
functions in transcriptional regulation, initiation of DNA replication and partitioning the viral …

While the majority of Human papillomavirus (HPV) infections are transient and cleared
within a couple of years following exposure, 10–20% of infections persist latently, leading to …

Acetylation of the RelA subunit of NF-κB at lysine-310 regulates the transcriptional activation
of NF-κB target genes and contributes to maintaining constitutively active NF-κB in tumors …

Animal and human papillomaviruses (HPVs) replicate persistently in specific types of
stratified epithelia of their host. After the initial infection, the viral genome replicates at low …

The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a
helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral …

It has long been recognized that oncogenic viruses often integrate close to common fragile
sites. The papillomavirus E2 protein, in complex with BRD4, tethers the viral genome to host …

The DNA damage response (DDR) maintains genomic integrity through an elaborate
network of signaling pathways that sense DNA damage and recruit effector factors to repair …

Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively
linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology …

Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …