The drama of Wallerian degeneration: the cast, crew, and script
K Zhang, M Jiang, Y Fang - Annual review of genetics, 2021 - annualreviews.org
Significant advances have been made in recent years in identifying the genetic components
of Wallerian degeneration, the process that brings the progressive destruction and removal …
of Wallerian degeneration, the process that brings the progressive destruction and removal …
Axonal degeneration as a therapeutic target in the CNS
Degeneration of the axon is an important step in the pathomechanism of traumatic,
inflammatory and degenerative neurological diseases. Increasing evidence suggests that …
inflammatory and degenerative neurological diseases. Increasing evidence suggests that …
The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein
Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and
injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 …
injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 …
[HTML][HTML] Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed
The molecular and cellular mechanisms underlying complex axon morphogenesis are still
poorly understood. We report a novel, evolutionary conserved function for the Drosophila …
poorly understood. We report a novel, evolutionary conserved function for the Drosophila …
Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence
M Lukacs, J Gilley, Y Zhu, G Orsomando… - Experimental …, 2019 - Elsevier
The three nicotinamide mononucleotide adenylyltransferase (NMNAT) family members
synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential …
synthesize the electron carrier nicotinamide adenine dinucleotide (NAD+) and are essential …
NMNAT: It's an NAD+ synthase… It'sa chaperone… It'sa neuroprotector
JM Brazill, C Li, Y Zhu, RG Zhai - Current Opinion in Genetics & …, 2017 - Elsevier
Highlights•NMNATs are highly conserved multifunctional neuronal maintenance
proteins.•NMNAT deficiency is genetically linked with neurodegenerative diseases.•NMNAT …
proteins.•NMNAT deficiency is genetically linked with neurodegenerative diseases.•NMNAT …
Phagocytosis and self-destruction break down dendrites of Drosophila sensory neurons at distinct steps of Wallerian degeneration
After injury, severed dendrites and axons expose the “eat-me” signal phosphatidylserine
(PS) on their surface while they break down. The degeneration of injured axons is controlled …
(PS) on their surface while they break down. The degeneration of injured axons is controlled …
Potential Therapeutic Benefit of NAD+ Supplementation for Glaucoma and Age-Related Macular Degeneration
Glaucoma and age-related macular degeneration are leading causes of irreversible
blindness worldwide with significant health and societal burdens. To date, no clinical cures …
blindness worldwide with significant health and societal burdens. To date, no clinical cures …
NMNATs, evolutionarily conserved neuronal maintenance factors
Proper brain function requires neuronal homeostasis over a range of environmental
challenges. Neuronal activity, injury, and aging stress the nervous system, and lead to …
challenges. Neuronal activity, injury, and aging stress the nervous system, and lead to …
The NAD+ salvage pathway modulates cancer cell viability via p73
The involvement of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in
cancer cell survival is poorly understood. Here we show that the NAD+ salvage pathway …
cancer cell survival is poorly understood. Here we show that the NAD+ salvage pathway …