Key Therapeutic Targets to Treat Hyperglycemia-Induced Atherosclerosis Analyzed Using a Petri Net-Based Model

A Rybarczyk, D Formanowicz, P Formanowicz - Metabolites, 2023 - mdpi.com
Chronic superphysiological glucose concentration is a hallmark of diabetes mellitus (DM)
and a cause of damage to many types of cells. Atherosclerosis coexists with glucose …

Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures

W Zhou, J Ås, C Shore-Lorenti… - Journal of Bone and …, 2024 - academic.oup.com
Several small genetic association studies have been conducted for atypical femur fracture
(AFF) without replication of results. We assessed previously implicated and novel genes …

[HTML][HTML] Isolation, characterization, and biological evaluation of ethanolic extract of Ajos sacha in Streptozotocin-induced hyperglycemia in Wistar albino rats

D Chutia, CK Tyagi, NR Bhuyan - South African Journal of Botany, 2022 - Elsevier
Diabetes mellitus is a metabolic endocrine disorder due to insulin imbalances associated
with microvascular and macrovascular complications. This research was aimed to explore …

Association between the rs1800624 and rs80096349 SNPs and diabetic retinopathy: a pilot study

HA Alnaji, AH Hasan, R Omran… - Ophthalmic …, 2024 - Taylor & Francis
Background One of the conditions that might harm your eyesight is diabetic retinopathy
(DR), DR may set in slowly but surely for those with long-term diabetes and poor glucose …

The outcome of sternum healing among diabetic patients undergoing open heart surgery: a literature review

TN Yahya, YE Sembiring… - Bali Medical …, 2022 - repository.unair.ac.id
Background: As part of the surgery, sternotomy is a common technique to expose the
underlying organs, allowing surgeons to explore the targeted organ. Despite the benefits …

Virtual screening for chemical analogues similar to phytochemicals that inhibit aldose reductase in the development of diabetic microvascular complications

F Otieno, R Kagia - F1000Research, 2023 - f1000research.com
Background: The polyol pathway contributes to the development of diabetic complications
but can be inhibited by plant phytochemicals. This study aimed at assessing analogs of …

Gene-based association analysis of a large patient cohort identifies potential genecandidates for atypical femur fractures

W Zhou, J Ås, C Shore-Lorenti, H Nguyen… - 2024 - diva-portal.org
Background: Several small genetic association studies have been conducted for atypical
femurfracture (AFF) without replication of results. We assessed previously implicated and …

Прогресування початкових стадій діабетичної непроліферативної ретинопатії та маркери глікування при цукровому діабеті 2-го типу

KV Korobov - Archive of Ukrainian Ophthalmology, 2022 - ophthalm.zaslavsky.com.ua
Актуальність. В розвитку та прогресуванні непроліферативної діабетичної ретинопатії
(НПДР) при цукровому діабеті 2-го типу (ЦД2) важлива роль належить активності …

Molecular Mechanisms of Interleukin-6 Trans-Signaling Mediated Effects on Endothelial Permeability, MÜLler Glia Dysfunction, and Vitreous Proteomic Alterations in …

RL Robinson - 2021 - search.proquest.com
Recent studies in our lab have demonstrated that interleukin 6 (IL-6) signaling through its
soluble receptor (IL-6 “trans-signaling”) plays a role in the pathogenesis of diabetic …

[PDF][PDF] ALDOSE REDUCTASE ENZYME'S CLINICAL AND THERMODYNAMIC CHARACTERISTICS IN THE SERUM OF IRAQI DIABETIC PATIENTS

HA ABASS - minarjournal.com
A superfamily of aldo-keto reductases includes the monomeric NADPH-dependent cytosolic
enzyme aldose reductase (AR). When hyperglycemia, increased glucose levels stimulate …