Regulation of gene expression in trypanosomatids: living with polycistronic transcription

C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features

PAM Michels, O Villafraz, E Pineda, MB Alencar… - Experimental …, 2021 - Elsevier
The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

The infection cushion of Botrytis cinerea: a fungal 'weapon' of plant‐biomass destruction

M Choquer, C Rascle, IR Gonçalves… - Environmental …, 2021 - Wiley Online Library
The necrotrophic plant‐pathogen fungus Botrytis cinerea produces multicellular appressoria
dedicated to plant penetration, named infection cushions (IC). A microarray analysis was …

Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation

G Taleva, M Husová, B Panicucci, C Hierro-Yap… - PLoS …, 2023 - journals.plos.org
The long slender bloodstream form Trypanosoma brucei maintains its essential
mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1 …

Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells

J Beauvarlet, P Bensadoun, E Darbo… - Nucleic Acids …, 2019 - academic.oup.com
G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and
telomere-independent mechanisms, but the inter-relationships among autophagy, cell …

[HTML][HTML] A leap into the unknown–early events in African trypanosome transmission

B Szöőr, E Silvester, KR Matthews - Trends in parasitology, 2020 - cell.com
African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been
good progress in understanding how the parasites prepare for transmission, detect their …

Sleeping sickness: a tale of two clocks

F Rijo-Ferreira, JS Takahashi - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild
animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic …

Fatty acid uptake in Trypanosoma brucei: Host resources and possible mechanisms

NR Poudyal, KS Paul - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Trypanosoma brucei spp. causes African Sleeping Sickness in humans and nagana, a
wasting disease, in cattle. As T. brucei goes through its life cycle in its mammalian and insect …

Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery

F Fall, L Mamede, L Schioppa, A Ledoux, P De Tullio… - Metabolomics, 2022 - Springer
Background Trypanosoma brucei is the causative agent of Human African Trypanosomiasis
(also known as sleeping sickness), a disease causing serious neurological disorders and …

Biogenesis and metabolic homeostasis of trypanosomatid glycosomes: New insights and new questions

PAM Michels, M Gualdrón‐López - Journal of Eukaryotic …, 2022 - Wiley Online Library
Kinetoplastea and Diplonemea possess peroxisome‐related organelles that, uniquely,
contain most of the enzymes of the glycolytic pathway and are hence called glycosomes …