Crohn disease: epidemiology, diagnosis, and management

JD Feuerstein, AS Cheifetz - Mayo Clinic Proceedings, 2017 - Elsevier
Crohn disease is a chronic idiopathic inflammatory bowel disease condition characterized
by skip lesions and transmural inflammation that can affect the entire gastrointestinal tract …

Crohn's disease

J Torres, S Mehandru, JF Colombel, L Peyrin-Biroulet - The Lancet, 2017 - thelancet.com
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with
increasing incidence worldwide. Crohn's disease might result from a complex interplay …

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda… - Nature …, 2022 - nature.com
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

M Zhang, E Viennois, M Prasad, Y Zhang, L Wang… - Biomaterials, 2016 - Elsevier
There is a clinical need for new, more effective treatments for chronic and debilitating
inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In this …

Biologic agents for IBD: practical insights

S Danese, L Vuitton, L Peyrin-Biroulet - … reviews Gastroenterology & …, 2015 - nature.com
Six biologic agents are currently approved for the treatment of IBD: four anti-TNF agents
(infliximab, adalimumab, golimumab and certolizumab pegol) and two anti-integrin agents …

The real-world effectiveness and safety of vedolizumab for moderate–severe Crohn's disease: results from the US VICTORY Consortium

PS Dulai, S Singh, X Jiang, F Peerani… - Official journal of the …, 2016 - journals.lww.com
The Real-World Effectiveness and Safety of Vedolizumab for M... : Official journal of the American
College of Gastroenterology | ACG The Real-World Effectiveness and Safety of Vedolizumab for …

Plant-derived exosomes as a drug-delivery approach for the treatment of inflammatory bowel disease and colitis-associated cancer

Y Cai, L Zhang, Y Zhang, R Lu - Pharmaceutics, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes
Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the …

Adalimumab monotherapy and a combination with azathioprine for Crohn's disease: a prospective, randomized trial

T Matsumoto, S Motoya, K Watanabe… - Journal of Crohn's …, 2016 - academic.oup.com
Abstract Background and Aims: The efficacy of azathioprine for Crohn's disease under
adalimumab treatment remains obscure. Methods: In an open-labelled prospective study …

The taxonomic composition of the donor intestinal microbiota is a major factor influencing the efficacy of faecal microbiota transplantation in therapy refractory …

P Kump, P Wurm, HP Gröchenig… - Alimentary …, 2018 - Wiley Online Library
Background Faecal microbiota transplantation is an experimental approach for the treatment
of patients with ulcerative colitis. Although there is growing evidence that faecal microbiota …

Predicting, preventing, and managing treatment-related complications in patients with inflammatory bowel diseases

L Beaugerie, JF Rahier, J Kirchgesner - Clinical Gastroenterology and …, 2020 - Elsevier
Risk of complications from specific classes of drugs for inflammatory bowel diseases (IBDs)
can be kept low by respecting contraindications. Patients with IBD frequently develop …