Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have
been progressively used by neuroscientists during the last several decades. The …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

Huntington's disease (HD) is a neurodegenerative disease characterized by movement and
cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that …

Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …

Tolerance occurs when, following an initial experience with a substance, more of the
substance is required subsequently to induce identical behavioral effects. Tolerance is not …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …

Mental illness remains the greatest chronic health burden globally with few in-roads having
been made despite significant advances in genomic knowledge in recent decades. The field …

Parkinson's disease (PD) is an age‐associated neurodegenerative condition in which some
genetic variants are known to increase disease susceptibility on interaction with …

The addictive properties of psychostimulants such as cocaine, amphetamine,
methamphetamine, and methylphenidate are based on their ability to increase …

General anesthetics disrupt brain network dynamics through multiple pathways, in part
through postsynaptic potentiation of inhibitory ion channels as well as presynaptic inhibition …