Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience
Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have
been progressively used by neuroscientists during the last several decades. The …
been progressively used by neuroscientists during the last several decades. The …
Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling …
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …
Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
JR Roth, RCM Moraes, BP Xu, SR Crawley… - Frontiers in Aging …, 2023 - frontiersin.org
Huntington's disease (HD) is a neurodegenerative disease characterized by movement and
cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that …
cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that …
The Stage-Based Model of Addiction—Using Drosophila to Investigate Alcohol and Psychostimulant Responses
PN Cummins-Beebee, MM Chvilicek… - International journal of …, 2023 - mdpi.com
Addiction is a progressive and complex disease that encompasses a wide range of
disorders and symptoms, including substance use disorder (SUD), for which there are few …
disorders and symptoms, including substance use disorder (SUD), for which there are few …
Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes
MM Chvilicek, A Seguin, DR Lathen… - Genes, Brain and …, 2024 - Wiley Online Library
Tolerance occurs when, following an initial experience with a substance, more of the
substance is required subsequently to induce identical behavioral effects. Tolerance is not …
substance is required subsequently to induce identical behavioral effects. Tolerance is not …
Drosophila learning and memory centers and the actions of drugs of abuse
C Larnerd, N Kachewar, FW Wolf - Learning & Memory, 2024 - learnmem.cshlp.org
Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …
abuse create strong, inappropriate, and lasting memories that contribute to many of their …
[HTML][HTML] Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man
Mental illness remains the greatest chronic health burden globally with few in-roads having
been made despite significant advances in genomic knowledge in recent decades. The field …
been made despite significant advances in genomic knowledge in recent decades. The field …
α‐Synuclein E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson's Disease
S Reiszadeh Jahromi, SR Ramesh… - Parkinson's …, 2021 - Wiley Online Library
Parkinson's disease (PD) is an age‐associated neurodegenerative condition in which some
genetic variants are known to increase disease susceptibility on interaction with …
genetic variants are known to increase disease susceptibility on interaction with …
The Use of Drosophila to Understand Psychostimulant Responses
TJ Philyaw, A Rothenfluh, I Titos - Biomedicines, 2022 - mdpi.com
The addictive properties of psychostimulants such as cocaine, amphetamine,
methamphetamine, and methylphenidate are based on their ability to increase …
methamphetamine, and methylphenidate are based on their ability to increase …
Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain
AD Hines, AB Kewin, MN Van De Poll… - Journal of …, 2024 - Soc Neuroscience
General anesthetics disrupt brain network dynamics through multiple pathways, in part
through postsynaptic potentiation of inhibitory ion channels as well as presynaptic inhibition …
through postsynaptic potentiation of inhibitory ion channels as well as presynaptic inhibition …