Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes

H Kaur, N Shekhar, S Sharma, P Sarma… - Pharmacological …, 2021 - Springer
Introduction COVID-19 cases are on surge; however, there is no efficient treatment or
vaccine that can be used for its management. Numerous clinical trials are being reviewed for …

The pharmacokinetics and metabolism of ivermectin in domestic animal species

AG Canga, AMS Prieto, MJD Liébana, NF Martínez… - The Veterinary …, 2009 - Elsevier
The pharmacokinetic properties of drugs are closely related to their pharmacological
efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption …

The approved dose of ivermectin alone is not the ideal dose for the treatment of COVID‐19

VD Schmith, J Zhou, LRL Lohmer - Clinical Pharmacology & …, 2020 - Wiley Online Library
Caly et al. 1 reported that ivermectin inhibited severe acute respiratory syndrome‐
coronavirus 2 (SARS‐CoV‐2) in vitro for up to 48 hours using ivermectin at 5 μM. The …

Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq

HA Hashim, MF Maulood, AM Rasheed, DF Fatak… - MedRxiv, 2020 - medrxiv.org
Objectives COVID-19 patients suffer from the lack of curative therapy. Hence, there is an
urgent need to try repurposed old drugs on COVID-19. Methods Randomized controlled …

Antiviral effect of high-dose ivermectin in adults with COVID-19: a proof-of-concept randomized trial

A Krolewiecki, A Lifschitz, M Moragas, M Travacio… - …, 2021 - thelancet.com
Background There are limited antiviral options for the treatment of patients with COVID-19.
Ivermectin (IVM), a macrocyclic lactone with a wide anti-parasitary spectrum, has shown …

Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: a randomized multi-center clinical trial

MS Niaee, P Namdar, A Allami, L Zolghadr… - Asian Pacific Journal …, 2021 - journals.lww.com
Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and
to evaluate the effect of ivermectin on mortality and clinical consequences. Methods: A …

[HTML][HTML] High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept …

D Buonfrate, F Chesini, D Martini… - International journal of …, 2022 - Elsevier
High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in
vitro. The aim of this study was to assess the safety and efficacy of high-dose ivermectin in …

Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin

GD de Melo, F Lazarini, F Larrous, L Feige… - EMBO molecular …, 2021 - embopress.org
The devastating pandemic due to SARS‐CoV‐2 and the emergence of antigenic variants
that jeopardize the efficacy of current vaccines create an urgent need for a comprehensive …

Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19

R Peña‐Silva, SB Duffull, AC Steer… - British journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Hundreds of researchers are working to develop a vaccine and are evaluating drugs to
mitigate the adverse health and economic consequences of COVID-19 (Coronavirus …

Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems

G Winzenburg, C Schmidt, S Fuchs, T Kissel - Advanced drug delivery …, 2004 - Elsevier
Biodegradable polymers have been extensively studied for numerous drug delivery systems
for human health purposes. The ever-increasing value of animals to human society allows …