Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Centrioles are among the largest protein-based structures found in most cell types,
measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate …

The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the
first large-scale serial electron tomography of whole mitotic spindles in early C. elegans …

Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial
polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin …

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

Centrosomes are cellular structures that nucleate microtubules. At their core is a pair of
centrioles that recruit pericentriolar material (PCM). Although centrosomes are considered …

Neurons are the basic information-processing units of the nervous system. In fulfilling their
task, they establish a structural polarity with an axon that can be over a meter long and …

Non-centrosomal microtubule organizing centers (ncMTOCs) are found in most
differentiated cells, but how these structures regulate microtubule organization and …

The formation of a functional spindle requires microtubule (MT) nucleation from within the
spindle, which depends on augmin. How augmin contributes to MT formation and …

The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely
associated with the centrosome during interphase. Conversely, the Golgi complex assumes …