Ubiquitination is a regulated post‐translational modification that conjugates ubiquitin (Ub) to
lysine residues of target proteins and determines their intracellular fate. The canonical role …

In recent years correlative microscopy, combining the power and advantages of different
imaging system, eg, light, electrons, X-ray, NMR, etc., has become an important tool for …

Cardiac injury in mammals and amphibians typically leads to scarring, with minimal
regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully …

Many biological functions depend critically upon fine details of tissue molecular architecture
that have resisted exploration by existing imaging techniques. This is particularly true for …

β-catenin is a protein involved in cell-cell adhesion and proliferation. In neoplastic diseases,
defects in the regulation of the cellular β-catenin content and cytoplasmic accumulation of …

We have characterized excisional wounds in the animal cap of early embryos of the frog
Xenopus laevis and found that these wounds close accompanied by three distinct …

The identities of the ubiquitin-ligases active during myogenesis are largely unknown. Here
we describe a RING-type E3 ligase complex specified by the adaptor protein, Ozz, a novel …

In the adult mammalian heart, the cardiomyocytes and thus their terminally anchored
myofibrillar bundles are connected by large arrays of closely spaced or even fused adhering …

In correlative microscopy, light microscopy provides the overview and orientation in the
complex cells and tissue, whereas electron microscopy offers the detailed localization and …

Array Tomography (AT) is a relatively easy-to-use and yet powerful method to put molecular
identity in its full ultrastructural context. Ultrathin sections are stained with fluorophores and …