Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Y Liang, X Sun, C Duan, S Tang, J Chen - Stem Cell Research & Therapy, 2023 - Springer
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration
and impose a considerable economic burden on patients and society, making efforts to cure …
and impose a considerable economic burden on patients and society, making efforts to cure …
Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins
A Blümke, E Ijeoma, J Simon, R Wellington… - Stem Cell Research & …, 2023 - Springer
Background Ever since their discovery, induced pluripotent stem cells (iPSCs) have been
extensively differentiated into a large variety of cell types. However, a limited amount of work …
extensively differentiated into a large variety of cell types. However, a limited amount of work …
[HTML][HTML] Automated human induced pluripotent stem cell colony segmentation for use in cell culture automation applications
Human induced pluripotent stem cells (hiPSCs) have demonstrated great promise for a
variety of applications that include cell therapy and regenerative medicine. Production of …
variety of applications that include cell therapy and regenerative medicine. Production of …
Cytocentric measurement for regenerative medicine
AD Henn, T Pereira, J Hunsberger, K Mitra… - Frontiers in Medical …, 2023 - frontiersin.org
Any Regenerative Medicine (RM) business requires reliably predictable cell and tissue
products. Regulatory agencies expect control and documentation. However, laboratory …
products. Regulatory agencies expect control and documentation. However, laboratory …
AMD and Stem Cell-Based Therapies
Age-related macular degeneration (AMD) is a complex disease characterized by the loss of
choroidal endothelial cells (CECs) with subsequent degeneration of the retinal pigment …
choroidal endothelial cells (CECs) with subsequent degeneration of the retinal pigment …
Robotic cell processing facility for clinical research of retinal cell therapy
M Terada, Y Kogawa, Y Shibata, M Kitagawa, S Kato… - SLAS Technology, 2023 - Elsevier
The consistent production of high-quality cells in cell therapy highlights the potential of
automated manufacturing. Humanoid robots are a useful option for transferring technology …
automated manufacturing. Humanoid robots are a useful option for transferring technology …
Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids
Autologous photoreceptor cell replacement therapy shows great promise for treating
patients with multiple forms of inherited retinal degenerative blindness. Specifically, in …
patients with multiple forms of inherited retinal degenerative blindness. Specifically, in …
Unravelling Stargardt disease (STGD1): modelling genotype-phenotype correlations and unresolved genetic variants in iPSC-derived retinal organoids
AM Watson - 2023 - theses.ncl.ac.uk
Stargardt disease (STGD1) is an inherited retinopathy affecting approximately 1: 8000
individuals. It is characterised by biallelic mutations in ABCA4 and encodes a vital protein for …
individuals. It is characterised by biallelic mutations in ABCA4 and encodes a vital protein for …