A practical guide to methods controlling false discoveries in computational biology

K Korthauer, PK Kimes, C Duvallet, A Reyes… - Genome biology, 2019 - Springer
Background In high-throughput studies, hundreds to millions of hypotheses are typically
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …

MultipleTesting. com: A tool for life science researchers for multiple hypothesis testing correction

O Menyhart, B Weltz, B Győrffy - PloS one, 2021 - journals.plos.org
Scientists from nearly all disciplines face the problem of simultaneously evaluating many
hypotheses. Conducting multiple comparisons increases the likelihood that a non-negligible …

Multiple testing with the structure-adaptive Benjamini–Hochberg algorithm

A Li, RF Barber - Journal of the Royal Statistical Society Series …, 2019 - academic.oup.com
In multiple-testing problems, where a large number of hypotheses are tested simultaneously,
false discovery rate (FDR) control can be achieved with the well-known Benjamini …

Adaptive novelty detection with false discovery rate guarantee

A Marandon, L Lei, D Mary, E Roquain - The Annals of Statistics, 2024 - projecteuclid.org
Adaptive novelty detection with false discovery rate guarantee Page 1 The Annals of Statistics
2024, Vol. 52, No. 1, 157–183 https://doi.org/10.1214/23-AOS2338 © Institute of Mathematical …

Conditional calibration for false discovery rate control under dependence

W Fithian, L Lei - The Annals of Statistics, 2022 - projecteuclid.org
Conditional calibration for false discovery rate control under dependence Page 1 The Annals of
Statistics 2022, Vol. 50, No. 6, 3091–3118 https://doi.org/10.1214/21-AOS2137 © Institute of …

Integrative conformal p-values for out-of-distribution testing with labelled outliers

Z Liang, M Sesia, W Sun - … of the Royal Statistical Society Series …, 2024 - academic.oup.com
This paper presents a conformal inference method for out-of-distribution testing that
leverages side information from labelled outliers, which are commonly underutilized or even …

Integrative conformal p-values for powerful out-of-distribution testing with labeled outliers

Z Liang, M Sesia, W Sun - arXiv preprint arXiv:2208.11111, 2022 - arxiv.org
This paper develops novel conformal methods to test whether a new observation was
sampled from the same distribution as a reference set. Blending inductive and transductive …

Clipper: p-value-free FDR control on high-throughput data from two conditions

X Ge, YE Chen, D Song, ML McDermott, K Woyshner… - Genome biology, 2021 - Springer
High-throughput biological data analysis commonly involves identifying features such as
genes, genomic regions, and proteins, whose values differ between two conditions, from …

Slotting metabolomics into routine precision medicine

M Mussap, A Noto, C Piras, L Atzori… - Expert Review of …, 2021 - Taylor & Francis
Introduction Despite an impressive amount of metabolomics studies in animal models and
humans, most findings have not yet translated into the clinical setting, and the road ahead …

[PDF][PDF] Machine learning meets false discovery rate

A Marandon, L Lei, D Mary, E Roquain - arXiv preprint arXiv:2208.06685, 2022 - arxiv.org
The aim is to detect novelties, namely Xis with Pi= P0. This task is illustrated in Figure 1 on a
classical image data set, where we want to detect hand-written digit '9's in the test sample …