The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

The NLRP1 inflammasome is a multiprotein complex that is a potent activator of
inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial …

Summary 2′, 3′-cGAMP, produced by the DNA sensor cGAS, activates stimulator of
interferon genes (STING) and triggers immune response during infection. Tremendous effort …

The limited host tropism of numerous viruses causing disease in humans remains
incompletely understood. One example is Zika virus (ZIKV), an RNA virus that has …

Host: pathogen interactions dictate the outcome of infection, yet the limitations of current
approaches leave large regions of this interface unexplored. Here, we develop a novel …

Viruses of wild and domestic animals can infect humans in a process called zoonosis, and
these events can give rise to explosive epidemics such as those caused by the HIV and …

In tropical and subtropical zones, arboviruses are among the major threats to human life,
affecting a large number of populations with serious diseases. Worldwide, over three …

Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

While the function of cGAS/STING signalling axis in the innate immune response to DNA
viruses is well deciphered, increasing evidence demonstrates its significant contribution in …