Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women
of reproductive age and is associated with various metabolic perturbations, in addition to …

Objective: The aim was to formulate practice guidelines for the diagnosis and treatment of
polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2
diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin …

PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a
metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia …

Polycystic ovary syndrome (PCOS) is now recognized to be the most common
endocrinopathy in women of reproductive age with a prevalence of 6.6–6.8%. PCOS, a …

As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

BACKGROUND AND PURPOSE The effects of metformin, an antidiabetic agent that
improves insulin sensitivity, on endothelial function have not been fully elucidated. This …

Insulin resistance refers to the state, wherein insulin action is insufficient to accomplish the
metabolic demands of peripheral tissues, despite the increased amounts of insulin secreted …