Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Increasing antibiotic resistance in multidrug-resistant (MDR) Gram-negative bacteria (MDR-
GNB) presents significant health problems worldwide, since the vital available and effective …

Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Colistin is increasingly used as an antibiotic of last resort for the treatment of carbapenem-
resistant Gram-negative infections. The plasmid-borne colistin resistance gene mcr-1 was …

Antimicrobial resistance is an urgent global health challenge in human and veterinary
medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however …

Cyanobacteria and microalgae are oxygen-producing photosynthetic unicellular organisms
encompassing a great diversity of species, which are able to grow under all types of extreme …

Since 2015, the discovery of colistin resistance genes has been limited to the
characterization of new mobile colistin resistance (mcr) gene variants. However, given the …

Objectives The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is
one of the most serious public-health issues in society today. Colistin is a last-resort …

Analysis of mcr-1-containing sequences identified a common∼ 2,607-bp DNA segment that
in many cases is flanked on one or both ends by IS Apl1. We present evidence that mcr-1 is …

Colistin-resistant multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-
resistant (PDR) bacteria are highly lethal and many researchers have tried hard to combat …