Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …

Bottom‐up proteomics is a mass spectrometric (MS)‐based approach for the
characterization of peptides obtained from in‐solution protein digestion. MS is favored over …

The inclusion of preliminary chemical labeling (derivatization) in the analysis process by
such powerful and widespread methods as electrospray ionization (ESI) and matrix-assisted …

The analysis of the qualitative and quantitative changes of metabolites in body fluids and
tissues yields valuable information for the diagnosis, pathological analysis and treatment of …

In this work, we developed a rapid and high-sensitivity method for simultaneous analyses of
fatty alcohols, fatty aldehydes, and sterols by combining the optimized derivatization reaction …

Mass spectrometry imaging has become a hot research field owing to its ability to reflect the
distribution of multiple metabolites in tissue. However, not all kinds of metabolites have great …

Currently, LC–MS has various applications in different areas such as metabolomics,
pharmacokinetics, and pathological studies. Yet, matrix effects resulting from co‐existing …

Currently in single-cell mass spectrometry, the analysis of low-abundance cell metabolites
such as fatty alcohols and sterols remains a challenge. In most research studies, single-cell …

Fatty acids (FAs) and fatty alcohols (FOHs) are essential compounds for maintaining life.
Due to the inherent poor ionization efficiency, low abundance, and complex matrix effect …

Abstract In this work, 0.08 mmol L− 1 of phthalic acid was introduced as a mobile phase
additive to quantify free amino acids (AAs) by hydrophilic interaction liquid chromatography …