In countries with a good standard of health care, intracranial haemorrhage (ICH) during the
neonatal period affects 3· 5–4· 0% of all haemophilia boys, which is considerably (40–80 …

Intracranial haemorrhage (ICH) is the most serious event in haemophiliacs, resulting in high
rates of mortality and disability. Although the use of a prophylaxis regimen has improved …

Background Patients with severe hemophilia A and factor VIII inhibitors are at increased risk
for serious bleeding complications and progression to end-stage joint disease. Effective …

Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors
and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of …

Intracranial haemorrhage (ICH) is the most serious type of bleeding for patients with
haemophilia. Prior published reports regarding ICH predate the widespread provision of …

The discussion of prophylactic therapy in haemophilia is largely focused on joint outcomes.
The impact of prophylactic therapy on intracranial haemorrhage (ICH) is less known. This …

Intracranial haemorrhage (ICH) is known to be a severe although uncommon complication
of haemophilia. A national survey has been conducted in France in order to collect …

Prophylaxis is considered optimal care for children and adults with severe haemophilia A
because of its proven ability to reduce joint and other bleeding episodes. However, a 'one …

Objective The aim of this study was to determine the economic burden from a societal
perspective and the health-related quality of life (HRQOL) of patients with haemophilia in …

Clinical experience since decades and numerous retro-and, recently, also prospective
studies clearly demonstrate that prophylactic treatment, albeit much more expensive, is …