African swine fever (ASF) is an acute and often fatal disease affecting domestic pigs and
wild boar, with severe economic consequences for affected countries. ASF is endemic in sub …

Animal diseases constitute a continuing threat to animal health, food safety, national
economy, and the environment. Among those, African swine fever (ASF) is one of the most …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …

The plant-specific proteins named PIN-FORMED (PIN) efflux carriers facilitate the direction
of auxin flow and thus play a vital role in the establishment of local auxin maxima within …

The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …

Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …

The Nef protein of HIV-1 downregulates the cell surface co-receptor CD4 by hijacking the
clathrin adaptor complex AP-2. The structural basis for the hijacking of AP-2 by Nef is …

Successful macrophage colonization by Coxiella burnetii, the cause of human Q fever,
requires pathogen-directed biogenesis of a large, growth-permissive parasitophorous …

BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from
the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral …