Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

The N‐myc downstream regulated gene (NDRG) family of proteins consists of 4 members,
NDRG1–4, which are well conserved through evolution. The first member to be discovered …

N-myc downstream-regulated gene 1 (NDRG1) is an intracellular protein that is induced
under a wide variety of stress and cell growth-regulatory conditions. NDRG1 is up-regulated …

Cancer cells use glucose and glutamine as the major sources of energy and precursor
intermediates, and enhanced glycolysis and glutamimolysis are the major hallmarks of …

Background & Aims Activating mutations in KRAS are detected in most pancreatic ductal
adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in …

We searched for potential suppressors of tumor metastasis by identifying the genes that are
frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively …

As a master switch for cell proliferation and differentiation, Myc exerts its biological functions
mainly through transcrip‐tional regulation of its target genes, which are involved in cells' …

Hypoxia inducible factor 1 (HIF-1), the key mediator of hypoxia signaling pathways, has
been shown involved in hypoxia-induced radioresistance. However, the underlying …

Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted
therapies. We and others previously reported the predominant role of tumor-suppressor …

The NDRG2 gene belongs to a family of N-Myc downstream-regulated genes (NDRGs) and
is expressed in many normal tissues. NDRG2 gene expression has been shown to be …