Interest of tumor targeting through EPR effect is still controversial due to intrinsic low
targeting efficacy and rare translation to human cancers. Moreover, due to different reasons …

The development of nanoparticle agents for MRI-guided radiotherapy is growing at an
increasing pace, with clinical trials now underway and many pre-clinical evaluation studies …

The use of radiosensitizing nanoparticles with both imaging and therapeutic properties on
the same nano-object is regarded as a major and promising approach to improve the …

Despite the great value of current exogenous contrast agents for providing main diagnostic
information, they still have certain drawbacks such as short blood half life, nonspecific …

Radiometals are increasingly used in nuclear medicine for both diagnostic and therapeutic
purposes. The DOTA ligand (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid) …

Tumor metastasis is a major cause of colorectal cancer-related deaths. The liver is a
common site of colorectal cancer metastasis. There is no effective treatment for patients with …

The purpose of this study was to investigate the radiation dose enhancement effects of
gadolinium-doped zinc oxide nanoparticles (Gd-doped ZnO NPs) under the megavoltage …

As nanoparticle solutions move towards human clinical trials in radiation therapy, the
influence of key clinical beam parameters on therapeutic efficacy must be considered. In this …

In this article, we report the safety evaluation of gadolinium-based nanoparticles in
nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in …

Clinical trials incorporating metallic nanoparticles (NPs) have recently begun. Radiotherapy
planning does not take into account NPs concentrations observed in the patients' target …