Abstract Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees
of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on …

Until the advent of modern neuroradiological imaging techniques in 1989, a diagnosis of GH
deficiency in adults carried little significance other than as a marker of hypothalamo-pituitary …

Context: Treatment with GH has been used to correct the growth deficit in children with GH
deficiency (GHD). Although successful in increasing height velocity, such treatment often …

We evaluated the dose-response effects of GH on the growth and growth factor levels of GH-
deficient patients. One hundred eleven short (− 3.0±0.9 height sd score), prepubertal GH …

Objective: To evaluate the efficacy of recombinant growth hormone for increasing adult
height in children treated for idiopathic isolated growth hormone deficiency. Design …

Growth hormone (GH) therapy has been appropriate for severely GH-deficient children and
adolescents since the 1960s. Use for other conditions for which short stature was a …

The therapeutic use of GH derived from human cadaveric pituitaries was introduced in the
late 1950s and early 1960s (1). Initially, supplies were severely limited, and few patients …

The growth hormone (GH)–IGF‐I axis is essential for normal foetal and childhood growth.
Defects at different sites in the axis frequently result in short stature which may compromise …

Background: The effectiveness of all prescribed treatments is contingent on patient
adherence. The reported levels of adherence to recombinant human growth hormone (r …

Advances in molecular biology have led to the identification of mutations within several
novel genes associated with the phenotype of isolated growth hormone deficiency …