The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …

Background During the last two decades, over 100 proteomics studies have identified a
variety of potential biomarkers in CSF of Alzheimer's (AD) patients. Although several reviews …

A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology
that precedes neuronal death and symptom onset, would be a much-needed prognostic …

Scope The aim of this study was to develop and evaluate a parallel reaction monitoring
mass spectrometry (PRM‐MS) assay consisting of a panel of potential protein biomarkers in …

A non-invasive and early-detectable peripheral biomarker is urgently needed for Alzheimer's
disease (AD). The present study is a step forward to verify the biomarker properties of …

Introduction Neurodegenerative diseases share common pathologic features including
neuroinflammation, mitochondrial dysfunction and protein aggregation, suggesting common …

Synapses are complex structures that allow communication between neurons in the central
nervous system. Studies conducted in vertebrate and invertebrate models have contributed …

Alzheimer's disease (AD) is a chronic, neurodegenerative brain disorder affecting millions of
Americans that is expected to increase in incidence with the expanding aging population …

Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disorder of aging, was long believed to be a non-genetic sporadic origin …

Alzheimer's disease (AD) onset and progression is influenced by a complex interplay of
several environmental and genetic factors, one of them gender. Pronounced gender …