Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

L Yan, K Xu, Q Xiao, L Tuo, T Luo, S Wang… - Frontiers in …, 2023 - frontiersin.org
Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore
immune function in most people living with human immunodeficiency virus (HIV). However …

Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: novel insights from microbial translocation and innate immunity

Q Xiao, F Yu, L Yan, H Zhao, F Zhang - Frontiers in Immunology, 2022 - frontiersin.org
After long-term anti-retroviral therapy (ART) treatment, most human immunodeficiency virus
(HIV)/Acquired Immure Deficiency Syndrome (AIDS) patients can achieve virological …

Leaky gut and severe adverse events in advanced hepatocellular carcinoma treated with lenvatinib

Y Fujimoto, T Namisaki, S Takeda, K Murata… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: To identify predictors of severe adverse events (≥ grade 3) in patients with
advanced hepatocellular carcinoma treated with lenvatinib. Patients and Methods: Of 41 …

Macrophage activation markers predict liver-related complications in primary biliary cholangitis

Y Fujinaga, T Namisaki, Y Tsuji, J Suzuki… - International Journal of …, 2022 - mdpi.com
Primary biliary cholangitis (PBC) has a wide variation in clinical presentation and course.
There is no significant correlation between these symptoms and the disease stage, although …

Identification of Diagnostic Markers Correlated With HIV+ Immune Non-response Based on Bioinformatics Analysis

R Bai, Z Li, Y Hou, S Lv, R Wang, W Hua… - Frontiers in Molecular …, 2021 - frontiersin.org
Background: HIV-infected immunological non-responders (INRs) are characterized by their
inability to reconstitute CD4+ T cell pools after antiretroviral therapy. The risk of non-AIDS …

Immune activation and inflammation in lactating women on combination antiretroviral therapy: role of gut dysfunction and gut microbiota imbalance

PT Munjoma, P Chandiwana, J Wyss… - Frontiers in …, 2023 - frontiersin.org
Introduction Combination antiretroviral therapy (cART) effectively controls HIV; however,
chronic low-level viremia and gut microbiota dysbiosis remain significant drivers of gut and …

Implications of Accumulation of Clonally Expanded and Senescent CD4 + GNLY+ T Cells in Immunological Non-responders of HIV-1 infection

X Yang, C Zhen, H Huang, Y Jiao, X Fan… - Emerging Microbes & …, 2024 - Taylor & Francis
Increased CD4+ GNLY+ T cells have been confirmed to be inversely associated with CD4+
T cell count in immunological non-responders (INRs), however, the underlying mechanisms …

HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity

WAJW Vos, A Navas, EMG Meeder… - Frontiers in …, 2024 - frontiersin.org
Introduction Immunological non-responders (INR) are people living with HIV (PLHIV) who
fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral …

S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation

J Boucher, C Gilbert, S Bose… - The Journal of …, 2024 - journals.aai.org
The study of S100A9 in viral infections has seen increased interest since the COVID-19
pandemic. S100A8/A9 levels were found to be correlated with the severity of COVID-19 …

Increased Microbial translocation is a prognostic biomarker of different Immune responses to ART in people living with HIV

X Tian, Y Xie, J Chen, W Yin, YL Zhao… - Infection and Drug …, 2023 - Taylor & Francis
Background Microbial translocation (MT) is a characteristic of human immunodeficiency
virus (HIV) infection. Whether MT is also a biomarker of different immune responses to …