Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic …

While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is
now recognized as a single disease whose diverse symptoms stem from the wide tissue …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …

G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors.
These receptors are natural allosteric proteins because agonist-mediated signaling by …

PDZ domains are protein-protein recognition modules that play a central role in organizing
diverse cell signaling assemblies. These domains specifically recognize short C-terminal …

To ensure that extracellular stimuli are translated into intracellular signals of appropriate
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …