The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
Hereditary influence in thoracic aortic aneurysm and dissection
Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …
Vascular smooth muscle cell plasticity and autophagy in dissecting aortic aneurysms
Objective—Recent studies suggested the occurrence of phenotypic switching of vascular
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …
Acute aortic syndromes
TT Tsai, CA Nienaber, KA Eagle - Circulation, 2005 - Am Heart Assoc
1. Acute aortic dissection is a disorder afflicting men more than women in their fifth and sixth
decades. The most common risk condition is hypertension. 2. Patients with aortic dissection …
decades. The most common risk condition is hypertension. 2. Patients with aortic dissection …
Aortic dissection: new frontiers in diagnosis and management: Part I: from etiology to diagnostic strategies
CA Nienaber, KA Eagle - Circulation, 2003 - Am Heart Assoc
ticular hypermobility, skin hyperextensibility, and tissue fragility. Eleven types of EDS have
been characterized; the true prevalence of EDS is unknown. An aggregate incidence of 1 …
been characterized; the true prevalence of EDS is unknown. An aggregate incidence of 1 …
Mutations in myosin light chain kinase cause familial aortic dissections
L Wang, D Guo, J Cao, L Gong, KE Kamm… - The American Journal of …, 2010 - cell.com
Mutations in smooth muscle cell (SMC)-specific isoforms of α-actin and β-myosin heavy
chain, two major components of the SMC contractile unit, cause familial thoracic aortic …
chain, two major components of the SMC contractile unit, cause familial thoracic aortic …
Molecular mechanisms of thoracic aortic dissection
D Wu, YH Shen, L Russell, JS Coselli… - Journal of Surgical …, 2013 - Elsevier
Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …
Pathogenesis of thoracic and abdominal aortic aneurysms
DC GUO, CL Papke, R He… - Annals of the New York …, 2006 - Wiley Online Library
The major disease processes affecting the aorta are aortic aneurysms and dissections.
Aneurysms are usually described in terms of their anatomic location, with thoracic aortic …
Aneurysms are usually described in terms of their anatomic location, with thoracic aortic …
Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E–deficient mice against atherosclerotic media destruction but differentially …
Background—Epidemiological and histological evidence implicates proteinases of the
matrix metalloproteinase (MMP) family in atherosclerosis and aneurysm formation. We …
matrix metalloproteinase (MMP) family in atherosclerosis and aneurysm formation. We …
Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and-9 in the …
AWY Chung, K Au Yeung, GGS Sandor… - Circulation …, 2007 - Am Heart Assoc
Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …